Gastrointestinal

This panel is not meant to be complete, but can be used as a starting point for GI. Locally used antibodies can always be added to the panel. We want to cover the most used antibodies in our panels and, where possible, add information/ papers on prefered antibodies over others. Please feel free to make remarks/ observations and let Sakura know.

Tumor of unknown origin -> (upper) GI
Cytokeratin-Pan	+
CK7	+
CK20	_
CDX2	+

Gastrointestinal:

Diagnosis	Commonly used biomarkers
Esophageal neoplasms	CK7	CK20	CDX2	MLH1	MSH2	MSH6
	PMS2	PD-L1	MUC2	p53	p40	CK5/6
	CK14	p16
Gastric neoplasms	CK7	CK20	CDX2	MLH1	MSH2	MSH6
	PMS2	MUC1	MUC2	MUC5AC	p53	Ki67
	CD34	ASMA	S100	HER2	Desmin	PD-L1
	CD20	CD79a	PAX5	CD5	CD10	CD23
Hepatocellular neoplasms	HepPar-1	Arginase-1	CEA	CD10	CK7	CK19
	CK20	CDX2	Glypican-3	SALL4	CD34	beta-Catenin
	AFP	EMA	CK17
Pancreatic neoplasms	CK7	CK20	CDX2	MLH1	MSH2	MSH6
	PMS2	CK19	Chromogranin	Synaptophysin	CD56	Ki67
	CK8/18	EMA	CEA	SMAD4	beta-Catenin	MUC1
	MUC2	MUC5AC
Small intestine neoplasms	CK20	CDX2	CK7	MLH1	MSH2	MSH6
	PMS2
Colorectal/ anal neoplasms	CK20	CDX2	CK7	MUC2	MLH1	MSH2
	MSH6	PMS2	SATB2	p53	Cadherin 17	CEA
	CK 5/6	CK14	p40	BRAFv600E	HER2	beta-Catenin
	GCDFP-15	p16
Neuroendocrine neoplasms	INSM1	Chromogranin	Synaptophysin	CD56	Ki67	Gastrin
GIST	DOG1	CD117	CD34	ASMA	S100	Desmin
Immune mediated/ autoimmune	CD3	PD-L1	IgG	IgG4	CD117
Infectious	CMV	H. pylori	HSV1	HSV2	EBER	p16/HPV
	Treponema pallidum
The bolded are the most used biomarkers