Breast panel

Differential diagnosis		Most commonly used biomarkers
Breast carcinoma		GATA3	Mammaglobin	GCDFP-15	ER	CK5/6	CK14
		CK8/18	CK7	CK20
	DCIS vs. infiltrating ductal carcinoma	p40	Myosin	Calponin	ASMA	CD10	p40/ Myosin
	Prognostic/ predictive	ER	PR	HER2	PD-L1	Ki67
	Ductal vs. Lobular adenocarcinoma	E-Cadherin	p120
	Metastatic breast carcinoma in sentinel nodes	CK7/19	Pan CK
	Triple-negative breast carcinoma	TRPS-1	ER	PR	HER2
	Atypical ductal hyperplasia vs. Usual ductal hyperplasia	CK5/6	CK7	CK14	CK18
Salivary gland type neoplasms		p40	CK7	CK14	CK8/18	CD117	ER
		PR	Ki67	GCDFP-15	Calponin	Myosin
Neuroendocrine neoplasms		INSM1	Chromogranin A	Synaptophysin	CD56	Ki67
Hematolymphoid neoplasms		CD45	CD3	CD20	CD10	BCL6	EBER
		PAX5	BCL2
Mesenchymal neoplasms		S100	SOX10	ERG	CD31	CD34	Podoplanin
		ASMA	Desmin
The list above does not include all differential diagnosis and related biomarkers. The bolded are the most commonly used biomarkers

Myoepithelial Cell Markers (MEC) used in breast pathology:

S100	Less sensitive and less specific for MEC's	8S Dwarakanath, AK Lee, RA Delellis, ML Silverman, L Frasca, HJ Wolfe:  S-100 protein positivity in breast carcinomas: a potential pitfall in diagnostic immunohistochemistry. Hum Pathol. 18:1144-1148 1987
SMA	Good staining of MEC's, but substantial staining of myofibroblasts
CK5/14	Good staining of MEC's. Be aware that acinar cells (close proximity to MEC's) are stained as well
Calponin	Specific to smooth muscle, but stains high percentage of myofibroblasts (76%)	22RW Werling, H Hwang, H Yaziji, AM Gown: Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain. Am J Surg Pathol. 27:82-90 2003
SMMS-1	Specific to smooth muscle, stains 8% of myofibroblasts
p63	Stains myoepithelium, but sometimes discontinuous epithelial layer, ánd reacts with a subset of breast tumor cells
SMMS-1/ p40	cocktail of these antibodies to easily identify difficult cases