CDX2

CDX2 is a transcription factor essential for differentiation of epithelium in the intestine, pancreas, and biliary tract. CDX2 is expressed in epithelial cells from the duodenum to rectum, including pancreas and
biliary tract

Intended use

It is a useful tool for identifying and classifying adeno-carcinoma and neuroendocrine tumor of the gastrointestinal tract when used with a panel of other antibodies

Specifications
product code: 8285-C010	Clone: EP25 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Appendix, pancreas, Tonsil
Associated panels: Carcinoma - general panel, Gastrointestinal, Dermatopathology
Assessment criteria
A strong nuclear staining reaction of all epithelial cells in the appendix
A weak to moderate and distinct nuclear staining reaction of virtually all intercalated duct epithelial cells in the pancreas
No nuclear or cytoplasmic staining must be seen in endothelial cells and smooth muscle cells in tonsil. The vast majority of lymphocytes should be negative, although weak nuclear staining reaction may be observed in a few lymphocytes