|
Differential diagnosis |
Most commonly used biomarkers | ||||||
|
Lung carcinoma |
TTF1 | Napsin A | CK7 | CK20 | CK5/6 | p40 | |
| DUO p40/ Napsin A | DUO CK5/6/ TTF1 | Calretinin | Podoplanin | WT1 | BAP1 | ||
| MTAP | |||||||
|
Adenocarcinoma vs Squamous cell carcinoma |
TTF1 | Napsin A | p40 | CK5/6 | DUO p40/ Napsin A | DUO CK5/6/ TTF1 | |
| Prognostic/ Predictive | PD-L1 | ALK | ROS1 | ||||
|
Adenocarcinoma vs Mesothelioma |
Calretinin | CK5/6 | WT1 | Podoplanin | BAP1 | MTAP | |
| EpCAM | CEA | CD15 | TTF1 | ||||
| Neuroendocrine neoplasms (incl. SCLC) | Synaptophysin | Chromogranin A | CD56 | TTF1 | Ki67 | INSM1 | |
|
Salivary gland type neoplasms |
Pan CK | p40 | EMA | S100 | SOX10 | ASMA | |
| Calponin | Myosin | CD117 | |||||
|
Hematolymphoid neoplasms |
CD45 | CD3 | CD20 | CD10 | BCL6 | EBER | |
| PAX5 | BCL2 | CD1a | CD207 | ||||
|
Mesenchymal neoplasms |
S100 | SOX10 | Melan A | Melanosome | ERG | CD31 | |
| CD34 | Podoplanin | ASMA | Desmin | Caldesmon | |||
|
The list above does not include all differential diagnosis and related biomarkers. The bolded are the most commonly used biomarkers |
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