Cytokeratin 20

Cytokeratin 20 (CK20) is a cytokeratin protein expressed in mature enterocytes and goblet cells of the gastric and intestinal mucosa

Intended use

Most colon adenocarcinomas, mucinous ovarian tumors, transitional cell and Merkel-cell carcinomas, gastric adenocarcinomas, bile system, and pancreas are CK20 positive. Most squamous cell carcinomas and adenocarcinomas from breast, endometrium, lung, and prostate maybe CK20 negative, as well as nonmucinous tumors of the ovary and small-cell lung carcinomas. The antibody labels CK20 protein in normal and neoplastic cells. It is a useful tool for classifying colonic epithelial lineage when used with a panel of antibodies.

Specifications
product code: 8304-C010	Clone: Ks20.8 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Appendix, tonsil
Associated panels:  Dermatopathology, Gastrointestinal, Lung panel
Assessment criteria
A strong, distinct cytoplasmic staining reaction of all surface epithelial cells in the appendix
An at least weak to moderate staining reaction in most crypt cells in the appendix
No staining of non-epithelial cells of the appendix
No staining in tonsil