CD34

CD34 is a transmembrane protein expressed on hematopoietic progenitor cells, capillary endothelial cells, rare glial cells in nervous tissues, and embryonic fibroblasts.

Intended use

The antibody labels CD34 protein in normal and neoplastic cells. The antibody recognizes a CD34 epitope that is resistant to neuraminidase, and sensitive to glycoprotease and chymopapain. It is a useful tool for classifying vascular and lymphatic tumors, and for sub-classifying leukemia when used with a panel of antibodies

Specifications
product code: 8268-C010	Clone: QBEnd/10 [Mouse]
Staining pattern: Membranous staining	Control tissue: Appendix, liver
Associated panels: Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong, predominantly membranous staining of Cajal cells in muscularis propria and stromal fibroblast-like cells in appendix
A moderate to strong, predominantly membranous staining of endothelial cells in portal tracts and periportal sinusoidal endothelial cells in liver (zone 1 sinusoids).
No staining reaction of the epithelial cells in the appendix and in the liver. Smooth muscle cells should be negative