Epithelial Membrane Antigen (EMA)

Epithelial Membrane Antigen (EMA) is a membrane protein expressed on the apical surface of secretory
glandular epithelial cells in a variety of tissues. The antibody labels EMA in normal and neoplastic cells.

Intended use

It is a useful tool for identifying adenocarcinomas derived from secretory epithelia such as metastases of breast carcinoma. It is also a useful tool for identifying malignant mesothelioma, renal cell carcinomas, and meningiomas when using with a panel of antibodies.

Specifications
product code: 8233-C010	Clone: E29 [Mouse]
Staining pattern: Membranous and cytoplasmic staining	Control tissue: Tonsil
Associated panels: Breast panel
Assessment criteria
A moderate to strong cytoplasmic staining of the majority of the intermediate and superficial squamous epithelial cells in the tonsil
An at least a weak predominantly membranous staining of the plasma cells in the tonsil
No staining in lymphocytes, endothelial cells or smooth muscle cells in tonsil