MUC1

MUC1 is a cell surface mucin glycoprotein and is expressed on the apical borders of most glandular epithelial cells, ductal epithelial cells, and some hematopoietic cell lineages. In neoplastic tissues, MUC1 may be expressed on the entire cell surface (depolarized expression). MUC1 is overexpressed in many human cancers, including non-small cell lung carcinoma (NSCLC) and breast carcinoma. MUC1 aberrant expression or overexpression is presented in cell membrane, cytoplasm and sometimes in nucleus.

Intended use

The anti-MUC1 antibody is useful for evaluation of tumor invasive growth and aggressiveness of carcinomas of the breast, stomach, colon, and renal cell carcinoma when used with a panel of other
antibodies

Specifications
product code: 8375-C010	Clone: ZM32 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Tonsil
Associated panels: Breast panel, Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong cytoplasmic staining of the majority of the intermediate and superficial squamous epithelial cells in the tonsil
An at least a weak predominantly membranous staining of the plasma cells in the tonsil