Synaptophysin

Synaptophysin is a calcium-binding glyco-protein expressed in the membranes of neuronal presynaptic
vesicles, as well as in vesicle membranes of neuroendocrine cells and the choroid plexus epithelium. Synaptophysin immunoreactivity is also observed in adrenal cortical cells, goblet cells, Paneth cells, and tumors of neuronal and neuroendocrine origin.

Intended use

The Tissue-Tek Genie anti-Synaptophysin Mouse Monoclonal Antibody [BS15] is thus a useful tool for identifying and classifying neuronal and neuroendocrine tumors, when used in a panel with other antibodies.

Specifications
product code: 8453-C010	Clone: BS15 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Appendix
Associated panels: Lung panel, Gastrointestinal
Assessment criteria
A strong, distinct cytoplasmic staining reaction of the axons of the Auerbach's and Meissner's plexus in the appendix
An at least weak to moderate staining reaction must be seen in the endocrine cells of the mucosa and the peripheral nerves situated in lamina propria mucosa in appendix
No staining must be seen in smooth muscle cells