MSH2

MSH2 (MutS homolog 2 protein) is expressed in normal proliferating cells and, when heterodimerized with MSH6, is involved in repairing DNA mutations which may occur during DNA replication. The antibody labels MSH2 protein in both normal and neoplastic cells. Lost expression or low levels of MSH2 protein are associated with colorectal and other cancers

Intended use

MSH2 is a useful tool for classifying tumors of the gastrointestinal tract, including associated extra colonic cancers such as endometrial and prostate cancers, when used with a panel of antibodies.

Specifications
product code: 8327-C010	Clone: RED2 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Tonsil,  colon adenocarcinoma with loss of MSH2
Associated panels: Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong nuclear staining reaction of the proliferating germinal centre B-cells in tonsil
At least weak to moderate distinct nuclear staining reaction of virtually all mantle zone B-cells and interfollicular lymphocytes in tonsil
I tissues with loss of MSH2, no nuclear staining reaction should be seen in the neoplastic cells, whereas a distinct nuclear staining reaction must be seen in stromal cells