CD10

CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), is a cell surface metallopeptidase expressed on early lymphoid progenitors, a small subset of immature B-cells, proliferating B-cells and mature neutrophils. CD10 is also expressed on various non-lymphoid cells including breast myoepithelial cells, bile canaliculi, fibroblast, renal glomerular and tubular epithelial cells, and small intestine epithelium

Intended use

The antibody labels CD10 in both normal and neoplastic cells. It is a useful tool for classifying Burkitt’s lymphoma, some follicular lymphoma, and renal cell carcinoma when used with a panel of antibodies.

Specifications
product code: 8253-C010	Clone: GM003 [Mouse monoclonal]
Staining pattern: Membranous/cytoplasmic staining	Control tissue: Kidney, tonsil
Associated panels: Carcinoma general panel, Lymphoma panel
Assessment criteria
A moderate to strong, predominantly membranous but also cytoplasmic staining reaction of virtually all epithelial cells in the renal proximal tubules and the parietal layer of the Bowman’s capsule
At least moderate, distinct membranous staining of virtually all germinal center B-cells in tonsil
No staining must be seen in the mantle zone B-cells and squamous epithelial cells
* Scattered neutrophils and endothelial cells will typically show a weak to strong staining reaction