p40

The ΔNp63 isoform, also known as p40, is the truncated or lacking the N-terminal domain and predominant isoform of p63. p40 is a nuclear protein and a transcription factor. It is confined to basal cells of squamous epithelia and urothelium, as well as basal cells/myoepithelial cells in breast, sweat gland, salivary gland, and prostate. Recent studies have shown that p40 is highly specific for squamous and basal cells and is superior to p63 for diagnosing lung squamous cell carcinoma.

Intended use

When used with a panel of other antibodies, anti-p40 antibody is a useful aid in differentiating lung squamous cell carcinoma from lung adenocarcinoma, and in identifying urothelial and myoepithelial neoplasms.

Specifications
product code: 8341-C010	Clone: BC28 [Mouse monoclonal]
Staining pattern: Nuclear staining	Control tissue: Tonsil, placenta, colon
Associated panels: Lung panel, Breast panel, Gastrointestinal, Dermatopathology
Assessment criteria	no scan available at this time
A moderate to strong, distinct nuclear staining reaction of virtually all squamous epithelial cells in the tonsil
An at least weak to moderate, distinct nuclear staining reaction of cytotrophoblasts must be seen in the placenta
No staining reaction should be seen in any cells in tonsil, except for squamous epithelial cells