CD3

CD3 is a complex of membrane proteins composed of five polypeptide chains that associate directly with the T-cell antigen receptor. CD3 is expressed on T-lymphocytes in the thymus, bone marrow, peripheral
lymphoid tissue and blood

Intended use

CD3 is expressed in the majority of T-cell neoplasms and is often not expressed in non-T-cell lymphoid malignancies. The antibody labels CD3 in both normal and neoplastic T-cells. It is useful for classifying T-cell neoplasms when used with a panel of other antibodies. It may also be used to highlight T-cell populations within a variety of tissues.

Specifications
product code: 8280-C010	Clone: EP177 [Rabbit monoclonal]
Staining pattern: Membranous staining	Control tissue: Tonsil, appendix
Associated panels: Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong and distinct predominantly membranous staining of all T-cells both in interfollicular T-zones and in germinal centers of the tonsil
An at least weak to moderate and distinct predominantly membranous staining reaction of dispersed intraepithelial T-cells in appendix
No staining of epithelial cells in appendix