Tumor of unknown Origin

In case of atumor of unknown origin, the following antibodies can help to make a first selection/ distinction:

Cytokeratin-Pan	S100 or SOX10	CD45	Vimentin
Carcinoma	Melanoma	Lymphoma	Sarcoma

Once the primary origin has been established, the next step would be to start with the general panels for the four different subgroups:

Carcinoma	Melanoma	Lymphoma	Sarcoma
CK7	Melan A	CD3	Desmin
CK20	Melanosome	CD5	Myogenin
	Ki67	CD10	CD117
	p16	CD21	ASMA
	p21	BCL2	Caldesmon
	SOX10	BCL6	CD31
		Ki67	ERG
		MUM1	SOX10
		CD20	CD99
		PAX5	STAT6
		CD23	NKX2.2
		CD30
		Cyclin D1
		TdT