Carcinoma - general panel

In case of known/ suspected carcinoma, but unknown origin, this table can be used to identify the tumor origin:

CK7	CK20	Origin	positive	negative
+	-	Lung	TTF-1, Napsin A	PAX8, GATA3
+	-	Breast	GCDFP15, Mammaglobin	PAX8, TTF-1
+	-	Ovary (non-mucinous)	PAX8, ER, WT1
+	-	Thyroid	Thyroglobulin, PAX8, TTF-1
+	-	Uterine Cervix	p16, CEA	ER, Vimentin
+	-	Upper GI	CDX2
+	-	Pancreas	SMAD4
+	-	Mesothelioma	CD10, PAX8
+	-	Renal Papillary Ca.	Calret, WT1, CK5/6	CEA
-	+	Colorectal Ca.	CDX2, SATB2
-	+	Merkel Cell Ca.	ALK (Lung)
-	+	Some upper GI
+	+	Urothelial Ca.	GATA3, Uroplakin II	PSA, NKX3.1
+	+	Pancreas
+	+	Ovary (mucinous)
-	-	Renal Clear Cell Ca.	PAX8
-	-	Liver	Hepatocyte, Arginase
-	-	Prostate	PSA, NKX3.1	Uroplakin II, GATA3, CDX2
-	-	Adrenal