CD56

CD56, also known as neuronal cell adhesion molecule (NCAM), is a membrane protein expressed in neurons and glial cells of the central nervous system, peripheral nerves and neuromuscular junctions of the peripheral nervous system, and in most types of neuroendocrine cells. CD56 is also expressed in various epithelial cells, smooth muscle cells, osteoblasts, natural killer (NK) cells and NK-like T-cells

Intended use

In neoplasms, CD56 is detected in certain large granular lymphocyte leukemias, small cell lung carcinomas, neural-derived tumors, myelomas, and myeloid leukemias. CD56 can be useful for identifying and characterizing NK-cell lymphoma, multiple myeloma, myeloid leukemia cells, some thyroid tumors, schwannoma, small cell carcinoma, neuroblastoma, and osteosarcoma when used with a panel of antibodies

Specifications
product code: 8274-C010	Clone: MRQ-42 [Rabbit]
Staining pattern: Membranous staining	Control tissue: Appendix, tonsil
Associated panels: Lung panel, Gastrointestinal
Assessment criteria
A moderate to strong, distinct predominantly membranous staining reaction of virtually all axons and ganglion cells in the nerve plexus of appendix
A strong, predominantly membranous staining reaction of virtually all the NK-cells and CD4/CD8 double positive T-cells in tonsil. The NK-cells should be clearly visible even at a very low magnification (2,5x objective)
No staining reaction in the columnar epithelial cells in appendix