CD15

CD15 is a membrane protein expressed by most terminally differentiated myeloid cells. Activated lymphocytes are CD15 protein positive, but the majority of lymphocytes are CD15 protein negative. Additionally, CD15 protein is expressed by a range of epithelial cell types.

Intended use

A number of hematologic malignancies and solid tumors also express CD15 protein, and Tissue-Tek Genie anti-CD15 Mouse Monoclonal Antibody may be useful for the diagnosis of classical Hodgkin’s lymphoma, characterization of acute leukemia, and differentiation of mesothelioma from lung adenocarcinoma when used with a panel of other antibodies.

Specifications
product code: 8256-C010	Clone: MMA [Mouse monoclonal]
Staining pattern: Membranous staining	Control tissue: Tonsil, kidney
Associated panels: Lung panel
Assessment criteria
A strong cytoplasmic staining reaction in neutrophil granulocytes in tonsil
A moderate to strong predominantly membranous staining reaction in virtually all the epithelial cells in proximal tubules of kidney
An at least weak but distinct predominantly membranous staining reaction of follicular dendritic cells in the germinal centres of the tonsil (this can be negative in some tonsils)
No staining reaction in B- and T-cells
* No or only minimal background reaction