Desmin

Desmin is an intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle). Desmin is also expressed in myofibroblasts and mesothelial cells but is absent in myoepithelial cells, malignant mesothelioma, and adenocarcinoma.

Intended use

Desmin is expressed in the majority of rhabdomyomas, leiomyomas, rhabdomyosarcomas, and leiomyosarcomas. It is a useful tool for subtyping undifferentiated and pleomorphic tumors when used
with a panel of antibodies.

Specifications
product code: 8311-C010	Clone: GM007 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Appendix
Associated panels: Tumor of Unknown Origin - Sarcoma, Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong, distinct cytoplasmic staining reaction of virtually all smooth muscle cells in lamina muscularis mucosae and muscularis propria of the appendix
At least weak cytoplasmic staining reaction of myofibroblasts lining the appendiceal epithelial cells
No staining reaction of the appendiceal epithelial cells