CD45

CD45 is a transmembrane protein which is also known as Leucocyte Common Antigen, LCA. It is expressed on most nucleated cells of hematopoietic origin and has various isoforms1.

Intended use

CD45 is detected in a large majority of hematopoietic-lymphoid neoplasms, i.e., leukemia and malignant lymphomas. Certain types of lymphoid neoplasms may lack CD45 expression (i.e. Hodgkin’s disease, some T-cell lymphomas, and some leukemia)2. The antibody is a useful tool for classifying tumor cells of  hematopoietic or lymphoid origin when used within a panel of antibodies.

Specifications
product code: 8271-C010	Clone: GR009 [Rabbit]
Staining pattern: Membranous staining	Control tissue: Tonsil, liver
Associated panels: Tumor of Unknown Origin
Assessment criteria
A moderate to strong and distinct predominantly membranous staining of lymphocytes. In tonsil, B-cell and T-cell should be distinctively stained
At least weak to moderate and distinct staining of Kupffer cells in liver
No staining of squamous epithelial cells in the tonsil or hepatocytes in the liver
Panels:
Tumor of unknown Origin