PAX5

PAX5, also designated B-cell specific activator protein (BSAP), is a transcription factor of the paired-box (PAX) containing family. PAX5 is important in control of B-cell commitment and shows nuclear expression in early progenitor B-cells and in all mature B-cells

Intended use

PAX5 is useful for subtyping lymphomas and lymphatic leukemias when used with a panel of antibodies.

Specifications
product code: 8500-C010	Clone: EP156 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Tonsil, Hodgkin lymphoma
Associated panels: Gastrointestinal
Assessment criteria
A distinct moderate to strong nuclear staining reaction of virtually all mantle zone B-cells, germinal centre B-cells and interfollicular peripheral B-cells in tonsil
An at least weak to moderate, nuclear staining reaction of virtually all Hodgkin and Reed-Sternberg cells in Hodgkins lymphoma
No staining reaction of other cells, including T-cells and squamous epithelial cells of tonsil