BCL2

BCL2 is a mitochondrial membrane protein expressed in lymphoid tissues (B-cells in mantle zone, interfollicular T-cell areas, and very few cells in the germinal center), and basal cells of epithelial tissues

Intended use

Bcl-2 positive results aid in the classification of follicular lymphomas and various diffuse lymphoproliferative disease

Specifications
product code: 8459-C010	Clone: EP36 [Rabbit monoclonal]
Staining pattern: Cytoplasmic staining	Control tissue: Appendix, tonsil
Associated panels: Lung panel
Assessment criteria
A moderate to strong, predominantly cytoplasmic staining reaction of virtually all T-cells and mantle zone B-cells of follicles in the tonsils and appendix
A weak to moderate, distinct cytoplasmic staining reaction of basal squamous epithelial cells and intra-germinal center T-cells in tonsil and of epithelial cells lining the basal compartment of the crypts in the appendix
No staining reaction of germinal centre B-cells in the tonsils and luminal epithelial cells of the appendix
*BCL2 Clone EP36 may label nucleoli, but this should not be interpreted as a clinically positive result