SOX10

SOX10 is a neural crest transcription factor involved in the determination of cell fate, maturation, and
maintenance of Schwann cells and melanocytes. The antibody labels SOX10 in both normal and neoplastic cells. SOX10 is expressed in glial cells, Schwann cells, myoepithelial cells (salivary, bronchial, and mammary glands), melanocytic nevi, a variety of neural crestderived tumors, some mesenchymal tumors, and some epithelial tumors.

Intended use

It is useful for identifying melanomas when used with a panel of other antibodies

Specifications
product code: 8308-C010	Clone: ZM10 [Rabbit monoclonal]
Staining pattern: Nuclear staining	Control tissue: Appendix, skin
Associated panels: Tumor of Unknown Origin, Dermatopathology
Assessment criteria
A strong, distinct nuclear staining reaction of virtually all Schwann cells in appendix, and of melanocytes in the skin
An at least moderate, distinct nuclear staining reaction of the majority of myoepithelial cells lining sweat glands in the skin
No reactions should be seen in columnar epithelial cells in appendix
*A weak cytoplasmic staining reaction in cells with a strong nuclear staining reaction is accepted
Panels:
Tumor of unknown Origin