S100B

S100 is a multigene family of calcium binding proteins. S100B is one member of the S100 family and is
expressed in glial cells of nervous system, melanocytes, chondrocytes, and adipocytes. The antibody labels S100B in normal and neoplastic cells.

Intended use

It is a useful tool for classifying tumors in nervous system and differentiating melanomas and nerve sheath tumors from carcinomas when used with a panel of antibodies

Specifications
product code: 8442-C010	Clone: EP324 [Rabbit]
Staining pattern: Nuclear and/or cytoplasmic staining	Control tissue: Appendix
Associated panels: Tumor of Unknown Origin, Gastrointestinal, Dermatopathology
Assessment criteria
A strong, distinct nuclear and cytoplasmic staining reaction of adipocytes and Schwann cells of peripheral nerve fibres in the appendix
A weak to moderate, cytoplasmic and nuclear staining reaction of the Peyer’s plaques in the appendix*
No staining of smooth muscle cells and epithelial cells in the appendix.
*S100B does not stain the Peyer's plaques in appendix
Panels:
Tumor of unknown Origin