ALK (Lung)

Anaplastic Lymphoma Kinase (ALK) is a transmembrane receptor tyrosine kinase. In normal tissue ALK is expressed in cells within a developing and mature nervous system including glial cells, neurons, endothelial cells, and pericytes. ALK was originally discovered as part of a fusion protein with nucleophosmin (NPM) produced by a translocation between the NPM and ALK genes and is the ALK fusion protein primarily associated with anaplastic large cell lymphoma (ALCL).

Intended use

The anti-ALK (Lung) antibody is useful for assessing ALK protein expression status in human lung carcinoma when used in a panel with other antibodies.

Specifications
product code: 8330-C010	Clone: 1A4[Mouse monoclonal]
Staining pattern: Cytoplasmic/nuclear staining	Control tissue: Appendix, tonsil, lung with ALK translocation
Associated panels: Carcinoma general panel, Lung panel
Assessment criteria
A moderate to strong, distinct cytoplasmic staining reaction of ganglion cells of the myenteric plexus in appendix
A weak to moderate staining reaction in dispersed axons of nerve cells in appendix
No staining in tonsil