Cytokeratin Pan

Cytokeratins is a group of intermediate filament proteins expressed in cells of epithelial origin. The antibody cocktail of clones AE1, AE3, and DC10 labels both acidic and basic cytokeratins in normal and neoplastic cells.

Intended use

It is a useful tool for classifying tumors of epithelial origin and undifferentiated carcinomas when used with a panel of antibodies

Specifications
product code: 8309-C010	Clone: AE1/AE3/DC10 [Cocktail]
Staining pattern: Cytoplasmic staining	Control tissue: Tonsil, liver
Associated panels: Tumor of Unknown Origin, Breast panel, Dermatopathology
Assessment criteria
A moderate to strong, distinct cytoplasmic staining reaction of virtually all squamous epithelial cells in tonsil
An at least moderate cytoplasmic staining reaction with membrane accentuation of the vast majority of hepatocytes in liver
No staining should be seen in lymphocytes in tonsil (Interstitial/ interdigitating reticulum cells may show a weak to moderate cytoplasmic staining reaction due to expression of CK8 and CK18)
Panels:
Tumor of unknown Origin