CD31

CD31, also known as platelet/endothelial cell adhesion molecule 1 (PECAM-1), is a trans-membrane  protein expressed on endothelial cells

Intended use

The antibody labels CD31 in normal and neoplastic cells. It is a useful tool for identifying vascular disorder, e.g. angiosarcoma, and evaluating vascularization of tumors when used with a panel of antibodies.

Specifications
product code: 8282-C010	Clone: RM247 [Rabbit]
Staining pattern: Membranous staining	Control tissue: Tonsil, liver, appendix
Associated panels: Tumor of Unknown Origin - Sarcoma, Dermatopathology
Assessment criteria
A strong and distinct, predominantly membranous staining of normal endothelial cells and plasma cells in tonsil
An at least weak to moderate, distinct membranous staining reaction of activated B- and T-cells, in particular mantle zone B-cells in the tonsil
At least weak to moderate staining of hepatic sinusoidal endothelial cells
No staining of the epithelial cells in appendix