Calponin

Calponin is a protein involved in the regulation of smooth muscle contraction and is expressed exclusively to vascular and visceral smooth muscle cells.

Intended use

Calponin is expressed in malignant myoepithelioma, pleomorphic adenoma of salivary gland, and angiomatoid malignant fibrous histiocytoma. Calponin is useful for differentiating normal and benign
sclerosing lesions of the breast from carcinoma when used with a panel of antibodies.

Specifications
product code: 8310-C010	Clone: EP63 [Rabbit monoclonal]
Staining pattern: Cytoplasmic staining	Control tissue: Gastrointestinal tract, breast
Associated panels: Breast panel
Assessment criteria
A moderate to strong staining of smooth muscle cells in the gastrointestinal tract
A moderate to strong staining of myoepithelial cells in lobules and ducts in normal breast