Myosin is one of the major contractile proteins in muscle and non-muscle cells. It involves in conversion of chemical energy into mechanical work. A Myosin molecule consists of two heavy chains (MHCs) and two pairs of light chains. MHCs have multiple isoforms. Smooth muscle myosin heavy chain is encoded by
MYH11 gene. It is expressed in visceral and vascular smooth muscle cells as well as myoepithelial cells
Intended use
Anti-Myosin Smooth Muscle antibody is useful for differentiating benign breast lesions and ductal carcinoma in situ (DCIS) from invasive breast carcinomas when used with a panel of other antibodies. The staining of myoepithelial layer is usually observed in the benign lesions and DCIS but not in the infiltrating carcinomas of breast. Anti-Myosin Smooth Muscle antibody is also useful for identifying smooth muscle cell tumors and myoepithelial tumors when used with a panel of other antibodies.
Specifications |
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product code: 8517-C010 |
Clone: SMMS-1 [Mouse] |
Staining pattern: Cytoplasmic staining |
Control tissue: Tonsil, appendix |
Associated panels: Breast panel |
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Assessment criteria |
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A moderate to strong and distinct cytoplasmic staining reaction of virtually all vascular smooth muscle cells in tonsil |
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An at least weak but distinct cytoplasmic staining of the vast majority of follicular dendritic cells in the germinal centers of tonsil |
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No staining must be seen in epithelial cells in appendix |
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