Melanosome

The antibody labels melanosome in the cytoplasm of activated and neoplastic melanocytes, such as fetal and neonatal melanocyte and junctional nevi, and melanomas. Intradermal nevi and normal resting adult melanocytes are negative. Positive staining does not provide distinction between benign and malignant melanocytic proliferation.

Intended use

It is a useful tool for classifying melanomas and melanocytic lesions and differentiating metastatic melanomas from other poorly differentiated tumors when using with a panel of antibodies

Specifications
product code: 8232-C010	Clone: HMB45 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Blue nevus/ angiomyolipoma, appendix
Associated panels: Dermatopathology
Assessment criteria
An at least weak to moderate cytoplasmic staining reaction of the majority of neoplastic cells of blue nevus or angiomyolipoma
No staining reaction in the skin with exception of scattered reactive melanocytes showing a weak to moderate cytoplasmic staining reaction
No staining reaction should be seen in appendix