Mammaglobin

Mammaglobin is a secretory protein and a mammaryspecific member of the uteroglobin family. Low level of expression of mammaglobin is seen in normal breast. Its expression is markedly increased in breast
carcinoma and is directly correlated with a higher grade. Mammaglobin is positive in about 80% of breast
carcinomas, and is more frequently expressed than GCDFP-15.

Intended use

Anti-mammaglobin antibody is useful for identification of breast carcinoma and metastatic tumor of  breast origin when used with a panel of other antibodies.

Specifications
product code: 8240-C010	Clone: EP249 [Rabbit]
Staining pattern: Cytoplasmic staining	Control tissue: Breast hyperplasia, skin, tonsil
Associated panels: Carcinoma - general panel,  Breast panel
Assessment criteria
A moderate to strong, distinct cytoplasmic reaction of at least scattered ductal epithelial cells lining the glands in breast hyperplasia
A moderate to strong, distinct cytoplasmic staining reaction of epithelial cells of the eccrine sweat glands in skin
No staining should be seen in in tonsil