Myosin Smooth Muscle (SMMS-1)

Myosin is one of the major contractile proteins in muscle and non-muscle cells. It involves in conversion of chemical energy into mechanical work. A Myosin molecule consists of two heavy chains (MHCs) and two pairs of light chains. MHCs have multiple isoforms. Smooth muscle myosin heavy chain is encoded by
MYH11 gene. It is expressed in visceral and vascular smooth muscle cells as well as myoepithelial cells

Intended use

Anti-Myosin Smooth Muscle antibody is useful for differentiating benign breast lesions and ductal carcinoma in situ (DCIS) from invasive breast carcinomas when used with a panel of other antibodies. The staining of myoepithelial layer is usually observed in the benign lesions and DCIS but not in the  infiltrating carcinomas of breast. Anti-Myosin Smooth Muscle antibody is also useful for identifying  smooth muscle cell tumors and myoepithelial tumors when used with a panel of other antibodies.

Specifications
product code: 8517-C010	Clone: SMMS-1 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Tonsil, appendix
Associated panels: Breast panel
Assessment criteria
A moderate to strong and distinct cytoplasmic staining reaction of virtually all vascular smooth muscle cells in tonsil
An at least weak but distinct cytoplasmic staining of the vast majority of follicular dendritic cells in the  germinal centers of tonsil
No staining must be seen in epithelial cells in appendix