GCDFP-15

Gross cystic disease fluid protein-15 (GCDFP-15) is a secretory glycoprotein and is expressed in the acinic
cells of the breast, salivary glands, sweat glands, and vesicular seminalis. GCDFP-15 is often expressed in neoplastic cells of breast carcinomas (50-70%), mammary and extramammary Paget’s disease, sweat gland tumors (particularly apocrine), and salivary gland tumors. Expression of GCDFP-15 in other adenocarcinomas is very rare. In the identification of the unknown primary cancer, GCDFP is a highly specific and fairly sensitive marker for breast carcinoma

Intended use

The anti-GCDFP-15 antibody is useful for identification of breast carcinoma and metastatic tumor of  breast origin when used with a panel of other antibodies.

Specifications
product code: 8325-C010	Clone: EP95 [Rabbit]
Staining pattern: Cytoplasmic staining	Control tissue: Breast hyperplasia, skin, tonsil
Associated panels: Carcinoma - general panel,  Breast panel, Dermatopathology
Assessment criteria
A moderate to strong, distinct cytoplasmic staining reaction of, at least, scattered ductal epithelial cells lining the glands in breast hyperplasia
A moderate to strong, distinct cytoplasmic staining reaction of the eccrine sweat glands in skin
No staining should be seen in tonsil
*A weak background staining can be expected