E-cadherin is a transmembrane cell adhesion glycoprotein that is critical for epithelial junction formation. E-cadherin is expressed in a majority epithelial cells. The expression of E-cadherin may be decreased or lost in malignant tumors.
Intended use
E-cadherin is positive in breast ductal carcinoma and negative in lobular carcinoma. E-cadherin is useful for differentiating between ductal and lobular breast carcinomas when used with a panel of antibodies.
Specifications |
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product code: 8269-C010 |
Clone: ZM63 [Mouse] |
Staining pattern: Membranous staining |
Control tissue: Appendix, liver |
Associated panels: Breast panel |
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Assessment criteria |
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A strong, distinct membranous staining reaction of virtually all the columnar epithelial cells in appendix |
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A strong, distinct membranous staining reaction of the epithelial cells of the bile ducts in the liver |
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An at least a weak to moderate membranous staining reaction of the hepatocytes in the liver |
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No staining reaction must be seen in stromal cells such as lymphocytes, plasma cells, smooth muscle cells or endothelial cells in appendix |
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