ERG

Erythroblast transformation-specific-related (ERG) protein is a transcription factor. ERG protein is involved in hematopoietic and endothelial development. It is expressed in endothelial cells of blood and lymphatic vessels, and bone marrow stem cells. In human prostate cancer, ERG protein is frequently overexpressed due to chromosomal translocations involving ERG and other genes. In particular, the TMPRSS2-ERG fusion gene is found in 45-65% of prostate cancers. TMRPSS2-ERG rearrangement detected by fluorescent in situ hybridization (FISH) have shown a strong correlation with ERG expression detected by IHC. ERG expression has been shown to be a highly specific marker for prostate cancer. ERG is expressed in  endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma.

Intended use

The anti-EGR antibody is useful for aid in diagnose of prostate cancer and vascular tumors when used with a panel of other antibodies. Clone EP111 is also named as EPR3864. This clone is capable to detect both wild-type and truncated ERG.

Specifications
product code: 8323-C010	Clone: EP111 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Tonsil, Appendix
Associated panels: Tumor of Unknown Origin - Sarcoma
Assessment criteria
A moderate to strong nuclear staining reaction of virtually all endothelial cells in the tonsil and the appendix
A weak to moderate nuclear staining reaction in peripheral T-cells and mantle zone B-cells is expected and accepted
No staining of epithelial cells and muscle cells