Mammaglobin

Mammaglobin is a secretory protein and a mammary specific member of the uteroglobin family. Low level of expression of mammaglobin is seen in normal breast. Its expression is markedly increased in breast
carcinoma and is directly correlated with a higher grade. Mammaglobin is positive in about 80% of breast
carcinomas, and is more frequently expressed than GCDFP-15.

Intended use

Anti-mammaglobin antibody is useful for identification of breast carcinoma and metastatic tumor of  breast origin when used with a panel of other antibodies.

Specifications
product code: 8240-C010	Clone: EP249 [Rabbit]
Staining pattern: Cytoplasmic staining	Control tissue: Breast hyperplasia, skin, tonsil
Associated panels: Carcinoma - general panel,  Breast panel
Assessment criteria
A moderate to strong, distinct cytoplasmic reaction of at least scattered ductal epithelial cells lining the glands in breast hyperplasia
A moderate to strong, distinct cytoplasmic staining reaction of epithelial cells of the eccrine sweat glands in skin
No staining should be seen in in tonsil