MSH6

MSH6 (MutS homolog 6 protein) is expressed in normal proliferating cells and, when heterodimerized with MSH2, is involved in repairing DNA mutations which may occur during DNA replication. Lost expression or low levels of MSH6 are associated with colorectal and other cancers.

Intended use

MSH6 is a useful tool for classifying tumors of the gastrointestinal tract, including associated extra colonic cancers such as endometrial and prostate cancers, when used with a panel of antibodies.

Specifications
product code: 8326-C010	Clone: EP49 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Tonsil, colon adenocarcinoma with loss of MSH6
Associated panels: Gastrointestinal, Dermatopathology
Assessment criteria
A moderate to strong nuclear staining reaction of the proliferating germinal centre B-cells in tonsil
At least weak to moderate distinct nuclear staining reaction of virtually all mantle zone B-cells and interfollicular lymphocytes in tonsil
I tissues with loss of MSH6, no nuclear staining reaction should be seen in the neoplastic cells, whereas a distinct nuclear staining reaction must be seen in stromal cells