C-MYC

C-Myc is a transcriptional factor which plays a role in the cell cycle progression and promotes cellular proliferation. C-Myc is expressed during proliferation in a wide variety of adult tissues and at all stage of
embryonic development.

Intended use

C-Myc gene translocation to various locations has been demonstrated in Burkett’s lymphoma, diffuse large B-cell lymphoma, blastic mantle cell lymphoma, and transformed follicular lymphoma. C-Myc expression has been described in various cancers including lymphomas, breast, prostate, lung and colon cancers. The anti-c-Myc antibody is useful for characterizing lymphoma and identifying B-cell lymphomas likely to harbor a c-Myc rearrangement when used with a panel of other antibodies.

Specifications
product code: 8332-C010	Clone: EP121 [Rabbit monoclonal]
Staining pattern: Nuclear staining	Control tissue: Tonsil, appendix
Assessment criteria
A moderate to strong, distinct nuclear staining reaction in approximately 10% of lymphocytes scattered both in the interfollicular zones and in the reactive germinal centers of the tonsil.
A weak, distinct nuclear staining reaction of mantle zone B-cells (app. 10-20%)
No nuclear staining reaction in the luminal epithelial cells of the appendix
* No or only very faint cytoplasmic staining reaction must be seen (basal epithelial cells will typically show moderate nuclear staining)