AMACR

AMACR, also known as P504S, is a mitochondrial enzyme expressed in many normal epithelia such as hepatocytes, tubular epithelia of kidney, epithelia of gall bladder, bronchial epithelia of lung, and colonic surface epithelia.

Intended use:

AMACR is positive in cells of premalignant high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma, but is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign hyperplasia.

Specifications:
product code: 8291-C010
Clone: 13H4 [Rabbit monoclonal]	Staining pattern: Cytoplasmic, granular
Host/ clonality: Rabbit monoclonal	Control tissue: Kidney, prostate
Assessment criteria:
A moderate to strong granular cytoplasmic staining of epithelial cells lining renal proximal tubules
A weak, granular cytoplasmic staining of epithelial cells of the renal distal tubules.
The epithelial cells of the prostate must be negative or only show a focal staining reaction
References:
1. Hameed O, et al. Am. J. Surg. Pathol. 2005; 29(5):579-587. Immunohistochemical Stains for p63 and a-Methylacyl-CoA Racemase, Versus a Cocktail Comprising Both, in the Diagnosis of Prostatic Carcinoma
2. Jiang Z, et al. Hum. Pathol. 2003; 34(8):792-796. Expression of a-Methylacyl-CoA Racemase (P504S) in Various Malignant Neoplasms and Normal Tissues: A Study of 761 Cases
3. Zhong Jiang, et al. Adv Anat Pathol 2004;11:316–321. Diagnostic utility of a-Methylacyl CoA Racemase (P504S) on Prostate Needle Biopsy