Beta-Catenin

Beta-catenin protein is a cell adhesion molecule that forms catenin-cadherin complex through binding to epithelial cadherin (E-Cadherin) protein at juxtamembrane sites. Beta-catenin protein is normally found in the cytoplasm at a submembranous location, but mutations in the beta-catenin gene can result in nuclear accumulation of the protein as has been demonstrated in fibromatosis lesions and in colorectal carcinoma.

Intended use

Anti-beta-catenin antibody is useful for diffenrentiating fibromatosis (desmoid tumor) from other fibroblast like lesions in various locations, including breast and mesentery, and for identifying colorectal cancer when used with a panel of antibodies

Specifications
product code: 8261-C010	Clone: EP35 [Rabbit monoclonal]
Staining pattern: Membranous staining	Control tissue: Colon, Liver
Associated panels: GI panel
Assessment criteria
A distinct membranous expression in all columnar epithelial cells of colon
A distinct membranous expression in the epithelial cells of the bile duct and an at least weak expression of hepatocytes