SOX2

SOX2 is one of embryonic stem cell transcription factors which is essential for maintenance of selfrenewal
and pluripotency in embryonic stem cells as well as adult tissue progenitor cells. SOX2 is expressed in multipotent neuronal stem cells in normal tissues. Overexpression of SOX2 is found in testicular germ cell
tumor, teratoma, astrocytic tumors, melanoma, various squamous cell carcinomas (e.g. cervical carcinoma,
lung cancer), and breast cancer with basal cell phenotype.

Intended use

SOX2 is useful for identifying lung squamous cell carcinomas (SCC), immature teratomas in the central nervous system (CNS), embryonal carcinoma, and distinguish seminoma testicular germ cell tumors (SOX2-) from non-seminoma germ cell tumors (SOX2+) when used in a panel of other antibodies.

Specifications
product code: 8228-C010	Clone: EP103 [Rabbit]
Staining pattern: Nuclear staining	Control tissue: Appendix, Testis
Associated panels: GI panel
Assessment criteria
A weak to moderate staining reaction of lymphocytes in appendix.
No staining is seen in other cells than lymphocytes in appendixA
n at least weak to moderate staining reaction in spermatogonia in testis