CD8

CD8 is a transmembrane protein expressed in mature cytotoxic/suppressor T-cells. The antibody labels CD8 protein in both normal and neoplastic cells

Intended use

It is a useful tool for classifying T-cell neoplasms and differentiating between cytotoxic and helper T-cells when used with a panel of antibodies.

Specifications
product code: 8252-C010	Clone:  C8/144B [Mouse monoclonal]
Staining pattern: Membranous and/or cytoplasmic staining	Control tissue: Tonsil, appendix
Associated panels: Dermatopathology
Assessment criteria
A strong and distinct membranous as well as cytoplasmic granular staining of normal suppressor/cytotoxic T-cells in tonsil
a strong, distinct membraneous staining of dispersed suppressor/cytotoxic T-cells primaly located in lamina propria mucosa, but also in the appendicieal epithelium
No staining reaction must be seen in B-cells, stromal cells or squamous epithelial cells of the tonsil. And no staining of epithelial cells in appendix