HER2

Human epithelial growth factor receptor 2 (HER2), also called c-erbB2, ERBB2, or HER2/neu, is a transmembrane protein that is expressed in a range of normal cells and tumors. Of significance is the finding that HER2 can be overexpressed in a percentage of such tumors, e.g. in 15-25% of breast cancers and in approximately 22% of gastric cancers

Intended use

The anti-HER2 antibody is useful for assessing HER2 protein expression status in human breast and  gastric/ gastroesophageal adenocarcinomas

Specifications
product code: 8388-C010, 8388-M250	Clone: EP3 [Rabbit monoclonal]
Staining pattern: Membranous staining	Control tissue: Breast cancer with/without HER2 expression
Associated panels: Breast panel
Assessment criteria	in progress
3+ Circumferential membrane staining that is complete, intense and in >10% of tumor cells
2+ Weak to moderate complete membrane staining observed in >10% of tumor cells
1+ Incomplete membrane staining that is faint/barely perceptible and in >10% of tumor cells
0 No staining is observed or membrane staining that is incomplete and is faint/barely perceptible and in ≤10% of tumor cells