p120

p120 catenin binds E-Cadherin at a juxta-membrane site while alpha-catenin and beta-catenin bind to the
intracellular domain of E-Cadherin. A deficiency of E-Cadherin results in the intracytoplasmic accumulation of p120 catenin. Membranous p120 catenin staining pattern is seen in many normal epithelial and nonepithelial tissues. Normal breast epithelium and in situ / invasive ductal carcinomas show membranous p120 catenin expression

Intended use

Diffuse cytoplasmic p120 catenin staining (without strong membranous staining) is seen in in situ / invasive lobular carcinoma and other lesions with dysfunctional E-cadherin / catenin tight junction. Anti-p120 catenin antibody is useful for classifying breast cancers when used with a panel of other antibodies.

Specifications
product code: 8373-C010	Clone: EP66 [Rabbit]
Staining pattern: Membranous and/or cytoplasmic staining	Control tissue: Tonsil
Associated panels: Breast panel
Assessment criteria
A strong staining reaction of squamous epithelial cells of tonsil
A weak to moderate staining reaction of germinal centre macrophages and the follicular dendritic network in tonsil