Neurofilament

Neurofilaments are cytoskeletal proteins normally found in neurons and axonal processes. They are often found in tumors of neural, neuroendocrine, and endocrine origin, including neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, paragangliomas, adrenal and extra-adrenal pheochromocytomas, and Merkel cell carcinoma.

Intended use

Anti-neurofilament antibody is a useful tool for identifying of tumors of neural, neuroendocrine, and endocrine origin, when used with a panel of antibodies.

Specifications
product code: 8289-C010	Clone: 2F11 [Mouse]
Staining pattern: Cytoplasmic staining	Control tissue: Appendix, Brain
Assessment criteria
The strongest possible reaction is shown in the ganglion cells and axons in the muscularis propria of the appendix. This without obtaining false positive reaction of other cells (enterocytes, lymphocytes, smooth muscle cells)
A moderate, distinct staining of perikarya/ganglion cells (appendix, brain)