DOG1

DOG1 is expressed predominantly on the plasma membrane of gastrointestinal interstitial cells of Cajal,
acinic cells in salivary glands, pancreatic centroacinar cells, and epithelium of the biliary tract, breast,
stomach, and prostate

Intended use

DOG1 is also expressed in gastrointestinal stromal tumors (GIST). DOG1 is an important marker in the identification of GIST together with CD117 (c-kit), and may be slightly more sensitive and more specific than CD117 (c-kit). Anti-DOG1 antibody is also a useful tool for identifying GIST that do not express CD117 (c-kit) protein, as well as for classifying salivary and renal carcinomas, when used with a panel of antibodies

Specifications
product code: 8368-C010	Clone: DOG1.1 [Mouse]
Staining pattern: Membranous staining	Control tissue: Appendix
Associated panels: Gastrointestinal
Assessment criteria
An at least moderate, distinct predominantly membranous staining reaction of the vast majority of Cajal cells in the appendix
A weak membranous staining reaction of the majority of columnar epithelial cells in the basal part of the crypts of the appendix
A weak membranous staining reaction of scattered endothelial cells and vascular smooth muscle cells in all included tissues
No staining reaction should be seen in mast cells and smooth muscle cells of muscularis propria and lamina muscularis mucosae