Cytokeratin 8 (LMW)

Cytokeratin 8 (CK8) is low molecular weight cytokeratin that is often co-expressed with cytokeratin 18.
Cytokeratin 8 is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the
luminal/secretory cells of complex epithelia

Intended use

Cytokeratin 8 is useful for the identification of adenocarcinomas of simple epithelial origin when used with a panel of other antibodies.

Specifications
product code: 8238-C010	Clone: EP17 [Rabbit]
Staining pattern: Cytoplasmic and sometimes membranous staining	Control tissue: Liver, Esophagus
Assessment criteria
A strong, distinct cytoplasmic staining reaction of virtually all appendiceal columnar epithelial cells, bile duct epithelial cells and an at least weak predominantly membraneous staining reaction of the large majority of the hepatocytes
An at least weak to moderate cytoplasmic staining reaction in the majority of the neoplastic cells of the colon neuroendocrine carcinoma.
A weak to moderate cytoplasmic staining reaction in smooth muscle cells and basal squamous epithelial cells of the esophagus