CD38

CD38 protein is a transmembrane glycoprotein that has an important role in the growth and differentiation of lymphoid and myeloid cells. CD38 protein is expressed in a wide range of cells, including hematopoietic and non-hematopoietic cells, with the highest expression levels typically seen in plasma cells. CD38 protein is found on immature cells of the B-cell and T-cell lineages, but is absent from most mature, resting peripheral lymphocytes. CD38 protein is also present on thymocytes, pre-B-cells, germinal center B-cells, mitogen-activated T-cells, Ig-secreting plasma cells, monocytes, NK cells, bone marrow erythroid and myeloid progenitor cells, and brain cells

Intended use

Anti-CD38 antibody is useful for identifying plasma cells and tumors with plasmablastic differentiation when used with a panel of antibodies

Specifications
product code: 8277-C010	Clone:  GM038 [Mouse]
Staining pattern: Membranous and cytoplasmic staining	Control tissue: Appendix, tonsil, liver
Assessment criteria
A strong, predominantly membraneous staining of peripheral nerves and the interfollicular NK-cells and a small subset of T-cells (CD4+ & CD8+ double positive)
Moderate to strong cytoplasmic and membraneous staining of activated late stage B-cells in germinal center and plasma cells in tonsil and appendix
A weak to moderate staining of fibroblastic reticular cells in tonsil and appendix, a proportion of smooth muscle cells and endothelial cells in the liver sinusoids
No staining reaction in the squamous epithelial cells of tonsil or the hepatocytes in liver.