CD23 is type II membrane glycoprotein and is primary expressed on the surface of a sub-population of B-cells in germinal center (mantle zone, and follicular dendritic cells)
Intended use
CD23 is detected in neoplastic cells from B-cell chronic lymphocytic leukemia/lymphoma (B-CLL) and absent in mantle cell lymphoma. It is a useful tool for identifying/classifying a range of leukemias and
lymphomas when used with a panel of antibodies
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Specifications |
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product code: 8262-C010 |
Clone: GR013 [Rabbit] |
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Staining pattern: Membranous staining |
Control tissue: Tonsil |
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Associated panels: Gastrointestinal |
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Assessment criteria |
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A strong, distinct staining of follicular dendritic cells in germinal centers of tonsil |
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At least weak to moderate and distinct membranous staining of activated B-cells in mantle zone of germinal centers of tonsil |
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No staining of T-cells or squamous epithelial cells in the tonsils |
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