CD19

CD19 is a member of immunoglobulin superfamily. CD19 regulates B-cell development, activation, and differentiation. CD19 is widely expressed from early pre-B-cells, normal B-cells, and normal plasma cells.
Its expression on normal plasma cells is weaker than normal B-cells and a subpopulation may lack expression. CD19 is also expressed on follicular dendritic cells

Intended use

CD19 is a specific and sensitive marker of B-cells, and is found on majority of B-cell neoplasms with some exceptions. The anti-CD19 antibody is useful for identification of majority B-cell neoplasm when used with a panel of other antibodies.

Specifications
product code: 8516-C010	Clone: EP169 [Rabbit monoclonal]
Staining pattern: Membranous staining	Control tissue: Tonsil, appendix
Assessment criteria
A strong, predominantly membranous staining of the mantle zone B-cells, the germinal centre B-cells, the interfollicular B-cells and follicular dendritic cells in tonsil
An at least weak to moderate membranous staining reaction of dispersed plasma cells, primarily located in the lamina propria of appendix
No staining in epithelial cells in appendix