CD13

CD13 is a heavily glycosylated membrane protein expressed by most cells of myeloid origin including monocytes, macrophages, granulocytes, and their hematopoietic precursors. CD13 is also abundantly expressed in the brush border of epithelial cells (e.g., renal proximal tubules, small intestine, prostatic epithelial cells), bile duct canaliculi, mast cells, bone marrow stromal cells, osteoclasts, and in some cases, in fibroblasts, and smooth muscle cells. CD13 antibody has been used as a myeloid marker

Intended use

It labels leukemic blasts in most acute myeloid leukemia (AML) and is useful in identifying AML and  subtype M0 of acute lymphoid leukemia (ALL). A canalicular staining pattern of CD13 is observed in both  normal and neoplastic liver tissues, and is useful in differentiation between hepatocellular carcinoma  (HCC) and non-HCC tumors  in liver when used in a panel with other antibodies

Specifications
product code: 8503-C010	Clone: EP117 [Rabbit monoclonal]
Staining pattern: Cytoplasmic staining	Control tissue: Liver, appendix
Assessment criteria
A stong staining reaction of bilecanaliculi in liver.
A moderate cytoplasmic staining reaction of virtually all cells in liver.
An at least weak staining reaction of lymphocytes in lamina propria in appendix.